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KMID : 0365819720120010329
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Journal of Pusan Medical College
1972 Volume.12 No. 1 p.329 ~ p.336
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The Effects of Adrenocortical Steroid and Sex Hormones on the Phosphorylase Activity of Pregnant Uterus and Uterine Myoma in Human
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Abstract
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In an attempt to examine the role of phosphorylase on the physiology of human uterus, experiments were conducted on the homogenates of non-pregnant and pregnant uteri and uterine myoma. The specimens were obtained from patients admitted in the Pusan University Hospital. The phosphorylase activity was determined according to the procedure described by Diamond and Brody. The effects of epinephrine, allotetrahydrocortisol and several sex hormones on the phosphorylase activity in the uterine tissues were studied, and the following results were obtained.
1) The phosphorylase activities in pregnant myometrium and uterine myoma were found to be fairly higher than that observed in non-pregnant myometrium.
2) Epinephrine caused an increase in the phosphorylase activity in non-pregnant and pregnant myometrium but exerted no appreciable effect on that of uterine myoma.
3) Beta-estradiol also markedly increased the phosphorylase activity in non-pregnant as well as pregnant myometrium but allotetrahydrocortisol failed to exert any effects. On the other hand, hydroxypregnenolone and dehydroisoandrosterone inhibited the phosphorylase activity in non-pregnant myometrium but not in pregnant myometrium and uterine myoma.
4) The increased phosphorylase activities in non-pregnant and pregnant myometrium by epinephrine was potentiated by beta-estradiol but not by allotetrahydrocortisol and other sex hormones.
5) It is interesting to note that the phosphorylase activity in the homogenate of uterine myoma was not affected by any of these hormones.
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KEYWORD
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